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KMID : 0382619880080020839
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Hanyang Journal of Medicine
1988 Volume.8 No. 2 p.839 ~ p.849
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Effects of Long-term Administration of Nicotine and Ethanol on the Blood Pressure and Body Weight in Spontaneously Hypertensive Rats
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Abstract
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Changes in the systolic pressure and body weight were studied in both sexes of spontaneously hypertensive rats treated chronically with nicotine (4.5mg/kg/day) or/and ethanol (2gm/kg/day) for 50 weeks. In the present study a total of 76 SHR at age of 5 weeks were employed and the experimental animals of each sex were fur-ther dividedinto the control (8), nicotine-treated (10), ethanol-treated (10) and nicotine plus ethanol- treated (10) groups.
The systolic pressures of the male and female control groups were elevated from 120mmHg to 170mmHg in 5 weeks and 11 weeks, respectively and thereafter blood pressure of both groups started to rise gradually again. In both sexes systolic pressures were significantly higher in the nicotine-treated and nicotine plus ethanol-treated groups as compared with the control group. However, no significant difference was . recognized between blood pressures of those two experimental groups.
On the other hand, the body weight of the nicotine-treated and the nicotine plus ethanol-treated groups were significantly lower than that of the control group but no significant difference was observed between body weight of two experimental groups. As with blood pressure the body weight of SHR was not influenced by ethanol in-gestion.
The results of present study indicate that nicotine significantly elevates blood pressure of and retards growth of SHR and that ethanol does not appear to affect effects of nicotine on the blood pressure and body weight in hypertensive animals.
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